Experimental research on Tenofovir vaginal gel (HIV Microbicide) for daily usage in women is successful, researchers just announced. This microbicide gel is very useful for women and will become very convenient to use without male consent. Tenofovir gel is a nucleotide reverse transcriptase inhibitor which acts by inhibiting this crucial enzyme. Researchers conducted experiments on 200 sexually active HIV-negative women in New York and Pune (National AIDS Research Institute) for six months. These research findings were presented at International microbicides meeting in New Delhi. National Institute of Health funded for this research. This Tenofovir gel has shown no side-effects on any major organs. 90% of women who participated in the survey said they would consider using the gel to prevent HIV transmission. Compliance and tolerance is good for this gel in women. Menstruation is the major cause for not using this gel in the experiment. More than 30 million people are living with AIDS and HIV is mainly spreading due to unsafe sex. 46% of HIV patients in the world are women who are infected mainly due to sexual contact. Please share your opinion on AIDS vaginal gel. … [Read more...]
FDA approved Isentress for AIDS
U.S. Food and Drug Administration (FDA) approved Merck’s Isentress (Raltegravir) for AIDS treatment. Isentress is an oral Integrase inhibitor, first in its class against HIV. FDA approved for Isentress use in combination with other antiretroviral agents for the treatment of HIV-1 infection. Isentress (400 mg) is a single tablet taken twice daily. Isentress can only control virus levels in the blood but can’t prevent transmission. Even though, Isentress showed good results in 80% of patients but its high price will limit its use. FDA approved after observing 24-week analysis data of clinical trials in 700 patients who are resistant to most anti-HIV medications. Mechanism of action of Isentress: Isentress is the first drug to be approved by FDA which works by inhibiting the insertion of HIV DNA into human DNA by the Integrase enzyme and limits the ability of the virus to replicate and infect new cells. Other drugs work by inhibiting Protease and Reverse Transcriptase enzymes. Isentress should always be prescribed in combination with other HIV drugs but not alone. Side effects of Isentress: Diarrhea is the most common side effect while nausea, headache and fever are other side effects. Myopathy and Rhabdomyolysis are rare adverse reactions with Isentress use. In America: More than 1 million Americans are living with AIDS and around 50,000 new cases are diagnosed each year. Worldwide: Around 40 million people are infected with HIV and 4.3 million new cases are diagnosed each year. 65% of these cases are reported from Sub-Saharan Africa. More than 3 million people died due to AIDS in 2006, according to World Health organization. I hope Merck will lower Isentress price to affordable level for the benefit of poor people. … [Read more...]
